doi:10.1038/ng.2337
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Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

       
       
        Xiangfeng Lu,1, 45 Laiyuan Wang,1, 2, 45 Shufeng Chen,1 Lin He,3 Xueli Yang,1 Yongyong Shi,3 Jing Cheng,4, 5 Liang Zhang,4 C Charles Gu,6 Jianfeng Huang,1 Tangchun Wu,7 Yitong Ma,8 Jianxin Li,1 Jie Cao,1 Jichun Chen,1 Dongliang Ge,1 Zhongjie Fan,9 Ying Li,1 Liancheng Zhao,1 Hongfan Li,2 Xiaoyang Zhou,10 Lanying Chen,1 Donghua Liu,1 Jingping Chen,1 Xiufang Duan,1
       
        We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10?8). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
       
       
来源：健康报